Asymmetric carbon-carbon bond-forming reaction at the 2-position of a piperidine skeleton |
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| Authors: | Kanda Yasuhisa Onomura Osamu Maki Toshihide Matsumura Yoshihiro |
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| Institution: | Department of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. |
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| Abstract: | An asymmetric carbon-carbon bond-forming reaction at the 2-position of a piperidine skeleton was exploited. This method consisted of a reaction between 1-(4-methoxybenzoyl)-3,4-didehydro-2-methoxypiperidines and dimethyl malonate catalyzed by Cu(II)-chiral 2,2'-isopropylidenebis(4-phenyl-2-oxazoline) to afford a 2-substituted piperidine skeleton with moderate enantioselectivity. |
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