L-histidine induced changes in adenosine 3':5'-monophosphate levels in rat brain and amounts of apo-, holo-a and holo-b fatty acid synthetases in rat liver. |
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Authors: | A A Qureshi J K Solomon B Eichelman |
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Affiliation: | 1. Laboratory of Behavioral Neurochemistry, Wm. S. Middleton VA Hospital Madison, Wisconsin 53705 USA;2. Waisman Center, University of Wisconsin Madison, Wisconsin 53705 USA |
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Abstract: | When fasted rats were fed a chow or fat-free diet supplemented 5% with L-histidine for three days, the brain adenosine 3′:5′-monophosphate (cAMP) level increased. A 50% increase occurred in rats fed a chow diet and 20% increase in rats fed a fat-free diet. Purification of liver fatty acid synthetase and the isolation of liver apo-, holo- and holo- fatty acid synthetases demonstrated that L-histidine feeding caused changes in the relative amounts of these enzymes. Apo- and holo- fatty acid synthetases increased while the holo- form simultaneously decreased. This effect was observed in rats fed either chow or fat-free diets supplemented with L-histidine. |
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