Advance of mitosis by histone phosphokinase |
| |
| Authors: | R J Inglis T A Langan H R Matthews D G Hardie E M Bradbury |
| |
| Institution: | 1. Department of Physics, Portsmouth Polytechnic, Gun House, Hampshire Terrace, Portsmouth, UK;2. Department of Pharmacology, University of Colorado, School of Medicine, Denver, CO 80220, USA |
| |
| Abstract: | The previous observation that growth-associated histone kinase (HKG) from Ehrlich ascites cells brings forward mitosis in Physarum polycephalum has been confirmed with more step 1 histone kinase and a more purified (step 2) histone kinase and the statistical significance of the results assessed. The mitosis appears normal in the phase contrast microscope and DNA synthesis is initiated after mitosis as usual. In vitro the growth-associated histone kinase phosphorylates chromatin, the phosphate appearing in F 1 histone. The results are interpreted as providing support for the hypothesis that growth-associated histone kinase controls the initiation of mitosis through F 1 histone phosphorylation and chromosome condensation. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
