Cloning and sequence analysis of the cDNA encoding a snake neurotoxin precursor |
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Authors: | T Tamiya A Lamouroux J F Julien B Grima J Mallet P Fromageot A Ménez |
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Abstract: | A recombinant plasmid has been constructed containing a sequence of 186 nucleotides encoding a potent neurotoxin found in the venom of the sea-snake Laticauda semifasciata and designated as erabutoxin a. This sequence is flanked, in the upstream region, by a sequence of 60 nucleotides encoding a hydrophobic peptide fragment presumably involved in the secretion process of the neurotoxin. The sequence coding for the toxin ends with a termination codon which is followed by a 3'-untranslated sequence of approximately 240 nucleotides (excluding the poly(A) tract). |
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Keywords: | clonage cDNA neurotoxine serpent cloning cDNA neurotoxin snake |
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