The heterogeneity of arylsulphatase-A and arylsulphatase-B in normal human urine and urine from cancer patients |
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Authors: | G Dowden R Davey |
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Institution: | Bill Walsh Cancer Research Laboratory, Royal North Shore Hospital of Sydney, St. Leonards, N.S.W., Australia. |
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Abstract: | Arylsulphatase-A and arylsulphatase-B heterogeneity in normal and cancer patient urine was investigated using high resolution agarose isoelectricfocusing. Normal urine contained up to nine forms of arylsulphatase-A activity with isoelectric points from 4.45 to 5.43 and at least 5 forms of arylsulphatase-B between 8.58 and 9.15 along with a broad zone of activity between pH 6.5 and 7.6. Although cancer patients had significantly higher levels of arylsulphatase-A and arylsulphatase-B activity, their pattern of activity was essentially the same as for the normals with only minor quantitative differences in some peaks. |
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