丙酮丁醇发酵菌的分子遗传改造

丙酮丁醇梭菌及拜氏梭菌是重要的ABE（丙酮、丁醇和乙醇）工业生产菌株，其发酵产物中的丙酮和丁醇均为重要的化工原料，汽车发动机试验证明丁醇还是一种性能优于乙醇的极具潜力的生物燃料和燃料添加剂。随着新生物技术的不断发展及工业生产的需求，遗传工程改造不断应用于丙酮丁醇生产菌株。在前人研究及工业实践的基础上,对丙酮丁醇生产菌株的遗传特性及其分子遗传改造取得的进展进行了详细概述。

Genetic Features and Modification of Clostridium acetobutylicum and Clostridium beijerinckii for Acetone Butanol and Ethanol Fermentation

Clostridium acetobutylicum and C.beijerinckii are extensively studied strains for producing ABE (Acetone, Butanol and Ethanol). Both acetone and butanol from ABE fermentation are widely used as important chemicals and raw materials. Butanol has been also recognized as a kind of potential biofuel or fuel additive with better performances than ethanol in the car engine tests. Genetic engineering has been broadly applied in the modification of these strains based on current industrial requirements and development of new biological technologies.The genetic features of C. acetobutylicum and C. beijerinckii, and progressive achievements on genetic manipulations of these strains  were reviewed.