Separation of the A gamma and G gamma cyanogen bromide peptides of human fetal hemoglobin by high-pressure liquid chromatography. |
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Authors: | T A Stoming F A Garver M A Gangarosa J M Harrison T H Huisman |
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Institution: | 2. Department of Medicine, College of Georgia, Augusta, Georgia 30901 USA |
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Abstract: | The Gγ and Aγ variants of human fetal hemoglobin are defined on the basis of a single glycine/alanine substitution at position 136 of the γ chain which is located in the carboxyterminal cyanogen bromide fragment (γCB-3). This communication describes the rapid separation of these two tridecapeptides by high-pressure liquid chromatography. Application of this new technique will facilitate the study of the biosynthesis and genetics of human fetal hemoglobin. |
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