Chromatin remodeling and repair of DNA double-strand breaks |
| |
Authors: | Lai-Yee Wong Judith Recht Brehon C. Laurent |
| |
Affiliation: | (1) Department of oncological sciences, Mount Sinai School of Medicine, Icahn Medical Institute, 1425 Madison Ave., New York, NY 10029, USA |
| |
Abstract: | Eukaryotic cells have developed conserved mechanisms to efficiently sense and repair DNA damage that results from constant chromosomal lesions. DNA repair has to proceed in the context of chromatin, and both histone-modifiers and ATP-dependent chromatin remodelers have been implicated in this process. Here, we review the current understanding and new hypotheses on how different chromatin-modifying activities function in DNA repair in yeast and metazoan cells. |
| |
Keywords: | Chromatin remodeling RSC Double-strand break DNA repair SWI/SNF Histone modifications Nucleosome Cohesin Cancer |
本文献已被 PubMed SpringerLink 等数据库收录! |