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Insights into Heptosyltransferase I Catalysis and Inhibition through the Structure of Its Ternary Complex
Authors:Markus Blaukopf  Liam Worrall  Paul Kosma  Natalie CJ Strynadka  Stephen G Withers
Institution:1. University of Natural Resources and Life Sciences – Vienna, Department of Chemistry, Muthgasse 18, 1190 Vienna, Austria;2. University of British Columbia, Department of Biochemistry and Molecular Biology, Life Sciences Centre, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada;3. University of British Columbia, Department of Chemistry, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada
Abstract:
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  • Keywords:glycosyltransferase  endotoxin  antivirulence  ADP-heptose  LPS biosynthesis  ternary complex  Gram-negative bacteria  C-glycoside  heptosyltransferase
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