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Crystal Structures of Fungal Tectonin in Complex with O-Methylated Glycans Suggest Key Role in Innate Immune Defense
Authors:Roman Sommer  Olga N Makshakova  Therese Wohlschlager  Stephanie Hutin  May Marsh  Alexander Titz  Markus Künzler  Annabelle Varrot
Institution:1. Chemical Biology of Carbohydrates, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), 66123 Saarbrücken, Germany;2. Univ. Grenoble Alpes, CNRS, CERMAV, 38000 Grenoble, France;3. Institute of Microbiology, Department of Biology, Swiss Federal Institute of Technology (ETH), 8093 Zürich, Switzerland;4. Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, 38000 Grenoble, France;5. Macromolecular Crystallography, Swiss Light Source, Paul Scherrer Institut, 5232 Villigen PSI, Switzerland;6. Deutsches Zentrum für Infektionsforschung, Standort Hannover-Braunschweig, Hannover, Germany
Abstract:
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  • Keywords:structural glycobiology  methylated glycans  innate immunity  multivalency  β-propeller  carbohydrates  lectins
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