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Structural Properties of the Human Protease-Activated Receptor 1 Changing by a Strong Antagonist |
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| Authors: | Patrizia M Spoerri Hideaki E Kato Moritz Pfreundschuh Stefania A Mari Tetiana Serdiuk Johannes Thoma K Tanuj Sapra Cheng Zhang Brian K Kobilka Daniel J Müller |
| Institution: | 1. Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule (ETH) Zurich, Basel 4058, Switzerland;2. Department of Cellular Physiology and Medicine, Stanford University School of Medicine, Palo Alto, CA 94305, USA |
| Abstract: |  |
| Keywords: | antagonist atomic force microscopy (AFM) conformations free-energy landscape G protein-coupled receptors (GPCR) ligand binding protease-activated receptor 1 (PAR1) single-molecule force spectroscopy (SMFS) unfolding vorapaxar |
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