Mitochondria, calcium and cell death: A deadly triad in neurodegeneration |
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Authors: | Fulvio Celsi Paola Pizzo Sara Leo Carmen Fotino Paolo Pinton Rosario Rizzuto |
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Affiliation: | a Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation (ICSI), Italy b Emilia Romagna Laboratory BioPharmaNet, University of Ferrara, Via Borsari 46, 44100 Ferrara, Italy c Department of Biomedical Sciences, University of Padova, Via Colombo 3, 35121 Padova, Italy d Department of Biochemistry, University of Padova, Viale G. Colombo, 3 35131 Padova, Italy e Department of Experimental Veterinary Sciences, University of Padova, Viale dell' Università 16, 35020 Legnaro, Italy |
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Abstract: | Mitochondrial Ca2+ accumulation is a tightly controlled process, in turn regulating functions as diverse as aerobic metabolism and induction of cell death. The link between Ca2+ (dys)regulation, mitochondria and cellular derangement is particularly evident in neurodegenerative disorders, in which genetic models and environmental factors allowed to identify common traits in the pathogenic routes. We will here summarize: i) the current view of mechanisms and functions of mitochondrial Ca2+ homeostasis, ii) the basic principles of organelle Ca2+ transport, iii) the role of Ca2+ in neuronal cell death, and iv) the new information on the pathogenesis of Alzheimer's, Huntington's and Parkinson's diseases, highlighting the role of Ca2+ and mitochondria. |
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Keywords: | Mitochondria Calcium Neurodegenerative disease Alzheimer's disease Parkinson's disease Huntington's disease |
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