Synthesis of chalcone derivatives on steroidal framework and their anticancer activities |
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Authors: | Saxena Hari Om Faridi Uzma Kumar J K Luqman Suaib Darokar M P Shanker Karuna Chanotiya Chandan S Gupta M M Negi Arvind S |
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Institution: | Central Institute of Medicinal and Aromatic Plants (CIMAP), P.O. CIMAP, Kukrail Picnic Spot Road, Lucknow, U.P., India. |
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Abstract: | Chalcone derivatives on estradiol framework have been synthesized. Some of the derivatives showed potent anticancer activity against some human cancer cell lines. Compounds 9 and 19 showed potent activity against MCF-7, a hormone dependent breast cancer cell line. Chalcone 7 was further modified to the corresponding indanone derivative (19) using the Nazarov reaction, which showed better activity than the parent compound against the MCF-7 breast cancer cell line. Active anticancer derivatives were also evaluated for osmotic hemolysis using the erythrocyte as a model system. It was observed that chalcone derivatives showing cytotoxicity against cancer cell lines did not affect the fragility of erythrocytes and hence may be considered as non-toxic to normal cells. |
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Keywords: | Chalcone Estradiol Anticancer Erythrocyte Osmotic fragility |
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