Attempt to Identify the Agent for Creutzfeldt-Jakob Disease by CF Antibody Relationship to Known Viruses |
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Authors: | PAUL BROWN,JOHN HOOKS,RAYMOND ROOS,D. C. GAJDUSEK,C. J. GIBBS Suffix" >JUN. |
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Affiliation: | 1.Laboratories of Slow, Latent and Temperate Virus Infections, National Institute of Neurological Diseases and Stroke, National Institutes of Health,Bethesda |
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Abstract: | CREUTZFELDT-JAKOB disease (C-J disease), a subacute spongiform virus encephalopathy responsible for a fatal presenile dementia of man, has been experimentally transmitted to the chimpanzee and passed serially from chimpanzee to chimpanzee1,2. The disease may be caused by the activation of a common virus which had remained latent after primary infection or by the development in vivo of a neurotropic variant of a common virus previously acquired. We have attempted to identify the agent of C-J disease by searching for serum antibodies to known viruses in thirteen patients and ten experimentally infected chimpanzees. Although we have failed to identify the causative agent, there is strong evidence against a serological relationship with any of the viruses tested. |
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