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The presence of aldolase C in rat hepatoma
Authors:T Sugimura  S Sato  S Kawabe
Affiliation:1. Center for Molecular Imaging, The University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA;2. Department of Radiology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA;3. Department of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA;4. Cellular and Molecular Biology Program, The University of Michigan Medical School, Ann Arbor, MI 48109, USA;5. Department of Biological Chemistry, The University of Michigan Medical School, Ann Arbor, MI 48109, USA;1. Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan;2. School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women''s University, 11-68 9-Bancho, Koshien, Nishinomiya 663-8179, Japan;3. Graduate School of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan;1. Experimental Nuclear Physics Department, Nuclear Research Center (NRC), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt;2. Central Laboratory for Elemental and Isotopic Analysis, Nuclear Research Center (NRC), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt;3. Accelerators and Ion Sources Department, Nuclear Research Center (NRC), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt;1. Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan;2. Pharmacokinetics and Non-Clinical Safety Department, Nippon Boehringer Ingelheim Co., Ltd., Kobe, Japan
Abstract:Aldolase A and hybrid molecules between aldolases A and C in a strain of Yoshida ascites hepatoma, AH143A of rat were found by electrophoresis on a cellulose acetate membrane. Results of column chromatography and inhibition by anti-aldolase A confirmed the presence of A3C hybrid molecule in this hepatoma. The significance of the aldolase C peptide in the hepatoma is discussed in relation to dis-differentiation.
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