Inhibitory effect of insulin on prostacyclin production by isolated rat adipocytes |
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| Authors: | Lloyd Axelrod Lawrence Levine |
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| Institution: | 1. Diabetes Unit and Medical Services, Massachusetts General Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA;2. Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02254, USA |
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| Abstract: | Physiologic concentrations of insulin completely inhibited the norepinephrine-induced increment in the production of 6-keto-prostaglandin (PG) F1α, the stable derivative of prostacyclin (PGI2), by isolated rat adipocytes. The inhibition of PGI2 production by insulin in isolated rat adipocytes supports the view that the elevated plasma level of 6-keto-PGF1α in rats with non-ketotic diabetes mellitus and diabetic ketoacidosis is derived at least in part from production of PGI2 by the adipocyte cell mass. |
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