A MASS FRAGMENTOGRAPHIC ASSAY OF 3-METHOXYTYRAMINE IN RAT BRAIN |
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| Authors: | C L Galli F Cattabeni T Eros P F Spano S Algeri A Di Giulio A Groppetti |
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| Institution: | Institute of Pharmacology and Pharmacognosy, University of Milan, 20129 Milan, Italy;Istituto Ricerche Farmacologiche 'Mario Negri' Via Eritrea 62, Milan, Italy;Institute of Pharmacology, School of Medicine, 2nd Chair, University of Milan, 20129 Milan, Italy |
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| Abstract: | Abstract— A mass fragmentographic method for the measurement of 3-methoxytyramine, a metabolite of dopamine formed after its neuronal release, is described. This method allows the assay of this dopamine metabolite in the picogram range, thus utilizing only few milligrams of brain areas containing dopaminergic neurons. Moreover, the method is simple and possesses the high specificity intrinsic to mass fragmentography. |
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