Cytotoxic triterpenoids from Ganoderma lucidum |
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| Authors: | Chun-Ru Cheng De-An Guo |
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| Institution: | Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Guo Shoujing Road 199, Zhangjiang Hi-Tech Park, Shanghai 201203, People’s Republic of China |
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| Abstract: | A systematic study of the metabolites in Ganoderma lucidum led to isolation of 43 triterpenoids, six of them (1-6) are hitherto unknown. The structures of the latter were elucidated on the basis of spectroscopic studies and comparison with the known related compounds. All of the compounds were assayed for their inhibitory activities against human HeLa cervical cancer cell lines. Some compounds exhibit significant cytotoxicity, and their structure-activity relationships are discussed. |
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| Keywords: | Ganoderma lucidum Triterpenoids Cytotoxicity Structure and activity relationship |
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