Diterpenoids from Pinus massoniana resin and their cytotoxicity against A431 and A549 cells |
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| Authors: | Nian-Yun Yang Wei-Wei Tao Li-Juan Tian |
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| Institution: | a Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China
b Technique Centre, Jinling Pharmaceutical Co., Ltd., Nanjing 210009, China |
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| Abstract: | Five diterpenoids and 14 known diterpenoids were isolated from the petroleum ether extract of Pinus massoniana resin. Their structures were elucidated by spectroscopic data interpretation. The cytotoxic activities of these compounds were evaluated using the MTT method. The results showed that three of the less polar diterpenoids had strong cytotoxicity against A431 and A549 cancer cells, whereas those of high polarity had none. |
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| Keywords: | Pine resin Pinus massoniana Pinaceae Diterpenoid Cytotoxicity A431 cell A549 cell |
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