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Daphnane diterpenoids isolated from Trigonostemon thyrsoideum as HIV-1 antivirals |
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| Authors: | Ling Zhang Rong-Hua Luo Ze-Jun Dong Yong-Tang Zheng |
| Institution: | a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People’s Republic of China b Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, People’s Republic of China c Graduate University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China |
| Abstract: | Four highly oxygenated daphnane diterpenoids, trigonothyrins D-G (1-4), were isolated from the stems of Trigonostemon thyrsoideum, and their structures were elucidated on the basis of extensive spectroscopic studies. Inhibitory activity against HIV-1 was assessed for compounds 1, 3 and 4, wherein, 3 showed activity with an EC50 value of 0.13 μg/mL and a therapeutic index (TI) of 75.1. |
| Keywords: | Trigonostemon thyrsoideum Euphorbiaceae Daphnane diterpenoids Trigonothyrins D-G Anti-HIV-1 |
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