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Saponins and a lignan derivative of Terminalia tropophylla from the Madagascar Dry Forest |
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| Authors: | Shugeng Cao Peggy J Brodie Richard Randrianaivo Vincent E Rasamison |
| Institution: | a Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, United States b Missouri Botanical Garden, B.P 3391, Antananarivo, Madagascar c Centre National d’Application des Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar |
| Abstract: | A study of an EtOH extract obtained from the roots of the Madagascan plant Terminalia tropophylla H. Perrier (Combretaceae) led to isolation of the oleanane-type triterpenoid saponin 1, the lignan derivative 2, and the two known saponins arjunglucoside I (3) and sericoside (4). The structures of compounds 1 (terminaliaside A) and 2 (4′-O-cinnamoyl cleomiscosin A) were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compound 1 showed antiproliferative activity against the A2780 human ovarian cancer cell line with an IC50 value of 1.2 μM. |
| Keywords: | Terminalia tropophylla Combretaceae Saponins Lignan NMR Antiproliferative activity |
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