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8,15-Epoxylabdane and norlabdane diterpenoids from Eragrostisviscosa |
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| Authors: | N’Soki N Sebastião Aldenir F dos Santos Célia Martins Carlos Diakanamwa Dina IMD de Mendonça |
| Institution: | a Chemistry Department, Agostinho Neto University, Luanda, Angola b Textile and Paper Materials Center and Chemistry Department, University of Beira Interior, 6200-001 Covilhã, Portugal c Chemistry Department, Federal University of Alagoas, 57092-970 Maceió-AL, Brazil d Department of Genetics, Faculty of Medical Sciences, New University of Lisbon, Lisbon, Portugal e Biology Department, Agostinho Neto University, Luanda, Angola |
| Abstract: | Four labdanes with a 8α,15-epoxy ring (8α,15-epoxylabdan-16β-oic acid; 8α,15-epoxy-16-norlabdan-13-one; 8α,15-epoxy-16-norlabdane; and 16-acetoxy-8α,15-epoxylabdane) and the known compound ambreinolide were isolated from the hexane extract of the aerial parts of the grass Eragrostis viscosa. The structures of all compounds were established based on spectroscopic data and the X-ray analysis of 8α,15-epoxy-16-norlabdan-13-one. The hexane extract presented moderate activity against the snail Biomphalaria glabrata. 8α,15-Epoxylabdan-16β-oic acid showed no mutagenic activity for doses up to 1000 μg/plate and no significant clastogenic activity for doses up to 100 μg/ml. |
| Keywords: | Eragrostis viscosa Poaceae Diterpenes 8 15-Epoxylabdanes Molluscicide activity Mutagenic activity Clastogenic activity |
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