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Cytotoxic triterpenoid saponins from the stem bark of Antonia ovata |
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| Authors: | Abdulmagid Alabdul Magid,Hé lè ne Bobichon,Nathalie Lalun,Christian Moretti |
| Affiliation: | a Laboratoire de Pharmacognosie, Institut de Chimie Moléculaire de Reims, CNRS UMR 6229, IFR 53 Biomolécules, Bâtiment 18, BP 1039, 51687 Reims Cedex 2, France b UMR CNRS 6237, Université de Reims Champagne-Ardenne, 51 Rue Cognacq-Jay, 51095 Reims Cedex, France c Laboratoire de Biologie Cellulaire, Génétique et Histologie, UFR de Médecine, 51 Rue Cognacq-Jay, 51095 Reims Cedex, France d Institut de Recherche Pierre Fabre, ISTMT, UMS CNRS 2597, 3 Rue des Satellites, BP 94244, 31432 Toulouse Cedex, France e IRD, UMR SAE 138, BP 529, Papeete, 98713 Tahiti, French Polynesia |
| Abstract: | Phytochemical investigation of the MeOH extract of the stem bark of Antonia ovata led to the isolation of four triterpenoid saponins, along with eleven known compounds. Their structures were established by extensive 1D and 2D NMR, as well as HR-MS analysis and acid hydrolysis. All isolated saponins contained the same tetrasaccharide chain O-β-d-xylopyranosyl-(1 → 2)-O-β-d-glucopyranosyl-(1 → 3)-O-[β-d-glucopyranosyl-(1 → 2)]-β-d-glucuropyranoside linked to C-3 of esterified derivatives of R1-barrigenol, A1-barrigenol, barringtogenol C, or camelliagenin. Biological evaluation of the compounds against KB cell line revealed a potent cytotoxic activity with IC50 values ranging from 3.1 to 6.6 μM. The known compounds were found to be inactive at 10 μg/ml concentration. |
| Keywords: | Antonia ovata Loganiaceae Triterpenoid saponins R1-barrigenol A1-barrigenol Barringtogenol C Camelliagenin Cytotoxic activity |
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