首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Correlation between beta-amyloid peptide production and human APP-induced neuronal death
Authors:Kienlen-Campard Pascal  Octave Jean-Noël
Institution:Université Catholique de Louvain, FARL/UCL 54 10, Av Hippocrate 54, B-1200 Brussels, Belgium.
Abstract:The production of amyloid peptide (Abeta) from its precursor (APP) plays a key role in Alzheimer's disease (AD). However, the link between Abeta production and neuronal death remains elusive. We studied the biological effects associated with human APP expression and metabolism in rat cortical neurons. Human APP expressed in neurons is processed to produce Abeta and soluble APP. Moreover, human APP expression triggers neuronal death. Pepstatin A, an inhibitor of aspartyl proteases that reduces Abeta production, protects neurons from APP-induced neurotoxicity. This suggests that Abeta production is likely to be the critical event in the neurodegenerative process of AD.
Keywords:
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号