Synthesis, characterization and bioactivity studies of novel beta-chitin scaffolds for tissue-engineering applications |
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Authors: | Maeda Y Jayakumar R Nagahama H Furuike T Tamura H |
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Institution: | Faculty of Chemistry, Materials and Bioengineering and High Technology Research Centre, Kansai University, Osaka 564-8680, Japan. |
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Abstract: | Chitin is a biopolymer and it is non-toxic, biodegradable and biocompatible. Chitin has many potential industrial applications because of its abundance, biodegradability, non-toxicity, chemical inertness. beta-Chitin scaffolds were prepared by using saturated calcium chloride alcoholic solution (CaCl(2).6H(2)O/EtOH) and then followed by dialysis with lyophilization. The prepared beta-chitin scaffolds were characterized by FT-IR, scanning electron microscopy (SEM) and thermogravimetric (TGA). The preliminary bioactivity studies of beta-chitin scaffolds were studied by using simulated body fluid (SBF) solution for 7, 14 and 21 days. We also immersed the beta-chitin scaffolds in saturated aqueous CaCl(2) and Na(2)HPO(4) solution over 12h. After 7, 14 and 21 days, the scaffolds were characterized by SEM and FT-IR studies. The SEM studies showed that there is a calcium phosphate layer in the surface as well as in the cross-section of beta-chitin scaffolds. It seems that the beta-chitin scaffolds are useful in the tissue-engineering field. |
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Keywords: | Chitin β -Chitin scaffolds Thermal studies Bioactivity Biomaterials |
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