Spatio-temporal modeling of signaling protein recruitment to EGFR期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Spatio-temporal modeling of signaling protein recruitment to EGFR

Authors:	Ming-yu Hsieh Shujie Yang Mary Ann Raymond-Stinz Jeremy S Edwards Bridget S Wilson

Affiliation:	(1) Department of Electrical and Computer Engineering, University of New Mexico, 1 University of New Mexico, Albuquerque, NM 87131, USA;(2) Department of Pathology, University of New Mexico Health Sciences Center, 1 University of New Mexico, Albuquerque, NM 87131, USA;(3) Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 1 University of New Mexico, 87131 Albuquerque, NM, USA;(4) Chemical and Nuclear Engineering, University of New Mexico, 1 University of New Mexico, 87131 Albuquerque, NM, USA;(5) The University of New Mexico Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, 1 University of New Mexico, Albuquerque, NM 87131, USA

Abstract:	Background A stochastic simulator was implemented to study EGFR signal initiation in 3D with single molecule detail. The model considers previously unexplored contributions to receptor-adaptor coupling, such as receptor clustering and diffusive properties of both receptors and binding partners. The agent-based and rule-based approach permits consideration of combinatorial complexity, a problem associated with multiple phosphorylation sites and the potential for simultaneous binding of adaptors.

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