A small library of trisubstituted pyrimidines as antimalarial and antitubercular agents |
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| Authors: | Agarwal Anu Srivastava Kumkum Puri S K Sinha S Chauhan Prem M S |
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| Affiliation: | Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India. |
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| Abstract: | A small library of 20 trisubstituted pyrimidines were synthesized and evaluated for their in vitro antimalarial and antitubercular activities. Out of the total screened compounds, 16 compounds have shown in vitro antimalarial activity against Plasmodium falciparum in the range of 0.25-2microg/mL and 8 compounds have shown antitubercular activity against Mycobacterium tuberculosis H(37)Ra, at a concentration of 12.5microg/mL. |
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