Ancistrolikokine D,a 5,8'-coupled naphthylisoquinoline alkaloid,and related natural products from Ancistrocladus likoko |
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Authors: | Bringmann Gerhard Saeb Wael Rückert Markus Mies Jan Michel Manuela Mudogo Virima Brun Reto |
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Institution: | Institut für Organische Chemie der Universit?t, Am Hubland, D-97074 Würzburg, Germany. bringman@chemie.uni-wuerzburg.de |
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Abstract: | A new naphthylisoquinoline alkaloid, ancistrolikokine D, and the likewise 5,8'-coupled alkaloid ancistroealaine A, as well as two further, biosynthetically related, but nitrogen-free natural products, ancistronaphthoic acid B and cis-isoshinanolone, have been isolated from Ancistrocladus likoko J. LEACUTE;ONARD (Ancistrocladaceae). The 5,8'-coupling of the new alkaloids and of the alkaloids isolated earlier hints at a close phylogenetic relationship of A. likoko to other Central African Ancistrocladus species. The compounds show moderate activities against Leishmania donovani, Trypanosoma cruzi, and Trypanosoma brucei rhodesiense. |
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Keywords: | Ancistrocladus likoko Ancistrocladaceae Structural elucidation Naphthylisoquinoline alkaloids Ancistrolikokine D Ancistroealaine A Ancistronaphthoic acid B Isoshinanolone Antiprotozoal activity |
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