Immunosuppression by avirulent,pseudohyphal forms ofCryptococcus neoformans |
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| Authors: | R Blackstock N K Hall |
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| Institution: | 1. Departments of Pediatrics and Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
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| Abstract: | Our previous reports have shown that animals inoculated for 8 weeks with 1 × 105 pseudohyphal, avirulentC. neoformans exhibited prolonged survival upon challenge with virulent cryptococci. This paper described a transient phase of immunosuppression which occurs during the initial weeks of the immunization protocol. Animals injected with pseudohyphal organisms had depressed responses to T and B-cell mitogens. In addition, they had lowered responses to immunization with sheep erythrocytes. Both humoral and cell mediated responses were affected. |
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