Synthesis and biological activity of amide derivatives of nimbolide |
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| Authors: | Sastry B S Suresh Babu K Hari Babu T Chandrasekhar S Srinivas P V Saxena A K Madhusudana Rao J |
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| Affiliation: | Natural Products Laboratory, Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Hyderabad. |
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| Abstract: | Nimbolide (1), a limonoid isolated from Azadirachta indica, is the chief cytotoxic principle in Neem leaves extract. Using nimbolide as a lead compound for anti-cancer analogue design, a series of nimbolide derivatives have been synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 10 compounds screened 2g, 2h and 2i showed potent activity. |
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