Experimental allergic orchitis in mice |
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| Authors: | Cory Teuscher Suzanne M Smith Ellen H Goldberg Gene M Shearer Kenneth S K Tung |
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| Institution: | (1) Departments of Pathology and Microbiology, The University of New Mexico School of Medicine, 87131 Albuquerque, New Mexico;(2) National Cancer Institute, National Institutes of Health (NIH), The Immunology Branch, 20205 Bethesda, Maryland |
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| Abstract: | Inbred strains of mice were studied for their susceptibility to the induction of experimental allergic orchitis after sensitization with mouse testicular homogenate in complete Freund's adjuvant accompanied by injections of extract from Bordetella pertussis. Susceptibility to autoimmune orchitis was found to be linked to the major histocompatibility complex in BALB/c and C57BL/10 mice and mapped to genes encoded within the H-2D
dregion. In five of six groups of bidirectional (susceptible × resistant) F1 hybrids, H-2D
d-linked susceptibility was inherited as a dominant autosomal trait. However, in (BALB/cByJ × DBA/2J)F1 and (DBA/2J × BALB/cByJ)F1 hybrids, dominant autosomal resistance to the induction of autoimmune orchitis was observed. Backcross analysis between the resistant F1 hybrid and the susceptible BALB/cByJ parent suggests that a single independently segregating DBA/2J locus is capable of negating H-2D
d-linked susceptibility, and controls resistance to the induction of autoimmune orchitis.Abbreviations used in this paper BP extract
Bordetella pertussis extract
- CFA
complete Freund's adjuvant
- EAO
experimental allergic orchitis
- Ir
immune response
- MHC
major histocompatibility complex
- MLH
mouse liver homogenate
- MTH
mouse testis homogenate
- PI
pathology index |
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