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Regulation of Cyclic AMP Accumulation in a Rat Sympathetic Ganglion: Effects of Vasoactive Intestinal Polypeptide
Authors:Robert L Volle  Brian A Patterson
Institution:Department of Pharmacology, University of Connecticut School of Medicine, Farmington, Connecticut, U.S.A.
Abstract:Cyclic AMP accumulation in rat superior cervical ganglia during synaptic activity occurs by a noncholinergic, nonadrenergic process. Both preganglionic nerve stimulation and 4-aminopyridine increase ganglion cyclic AMP levels in the presence of atropine or phentolamine. Of the polypeptides tested as putative transmitters, vasoactive intestinal polypeptide (10(-6) M) causes ganglion cyclic AMP accumulation comparable to that produced by preganglionic nerve stimulation.
Keywords:Ganglion cyclic AMP  Vasoactive intestinal polypeptide  Synaptic cyclic AMP regulation  4-Aminopyridine
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