Regulation of Cyclic AMP Accumulation in a Rat Sympathetic Ganglion: Effects of Vasoactive Intestinal Polypeptide |
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| Authors: | Robert L Volle Brian A Patterson |
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| Institution: | Department of Pharmacology, University of Connecticut School of Medicine, Farmington, Connecticut, U.S.A. |
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| Abstract: | Cyclic AMP accumulation in rat superior cervical ganglia during synaptic activity occurs by a noncholinergic, nonadrenergic process. Both preganglionic nerve stimulation and 4-aminopyridine increase ganglion cyclic AMP levels in the presence of atropine or phentolamine. Of the polypeptides tested as putative transmitters, vasoactive intestinal polypeptide (10(-6) M) causes ganglion cyclic AMP accumulation comparable to that produced by preganglionic nerve stimulation. |
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| Keywords: | Ganglion cyclic AMP Vasoactive intestinal polypeptide Synaptic cyclic AMP regulation 4-Aminopyridine |
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