The deubiquitinase emperor's thumb is a regulator of apoptosis in Drosophila |
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| Authors: | Jeronimo P. Ribaya Jeff Copeland Adrienne P. Blair Frank A. Laski |
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| Affiliation: | a Department of Molecular Cell and Developmental Biology, and Molecular Biology Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA
b Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA |
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| Abstract: | We have characterized the gene emperor's thumb (et) and showed that it is required for the regulation of apoptosis in Drosophila. Loss-of-function mutations in et result in apoptosis associated with a decrease in the concentration of DIAP1. Overexpression of one form of et inhibits apoptosis, consistent with et having an anti-apoptotic function; however, overexpression of a second form of et induces apoptosis, indicating that the two forms of et may have competing functions. et encodes a protein deubiquitinase, suggesting it regulates apoptosis by controlling the stability of apoptotic regulatory proteins. |
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| Keywords: | Apoptosis emperor's thumb Drosophila Deubiquitinase |
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