Tailoring immunoglobulin Fc for highly potent and serum-stable therapeutic antibodies |
| |
Authors: | Sang Taek Jung |
| |
Institution: | 1. Department of Bio and Nano Chemistry, Kookmin University, Seoul, 136-702, Korea
|
| |
Abstract: | Antibody Fc region, a recruiter and a frontline commander in the combat against cancer and infectious pathogens, mediates potent immune effector functions by engaging Fc receptors and serum complement proteins. Recent studies indicate that the Fc region is particularly amenable to modifications that enhance potency and serum stability through amino acid substitution and glycan modification. In order to modulate the interaction of the Fc domain with Fc-binding ligands (FcγRs, C1q, and FcRn), various engineering strategies have been employed; these studies are discussed in this review. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|