Deletion mapping of 39 random isolated Y-chromosome DNA fragments |
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Authors: | C J J Oosthuizen J S Herbert L K Vermaak J Brusnicky J Fricke L du Plessis A E Retief |
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Institution: | (1) MRC Cytogenetics Research Unit, Department of Human Genetics, Tygerberg Hospital, P. O. Box 63, 7505 Tygerberg, Republic of South Africa |
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Abstract: | Summary Thirty-nine recombinants isolated from a Y chromosome-specific library were deletion mapped. Seven deletion intervals were defined by hybridization of probes to DNA of eight individuals with aberrant Y chromosomes. Extreme cytogenetic limits of the deletion intervals were determined by in situ hybridization of one probe per deletion interval. Five intervals, with a total of twenty-five probes, were allocated to the longarm euchromatic region. The probes described will be useful for characterization of aberrant Y chromosomes, in searching for expressed sequences on the Y chromosome, and for further study of the evolutionary relationship between the Y chromosome and other chromosomes. |
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