Postnatal development of a demyelinating disease in avian spinal cord chimeras |
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| Authors: | M Kinutani M Coltey N M Le Douarin |
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| Institution: | 1. Faculty of Medicine, McGill University, Montreal, Canada;2. Faculty of Dentistry, McGill University, Montreal, Canada;1. Department of Biopsychology, Institute of Cognitive Neuroscience, Ruhr-University Bochum, 44780 Bochum, Germany;2. Stellenbosch Institute for Advanced Study (STIAS), Wallenberg Research Centre at Stellenbosch University, Stellenbosch 7600, South Africa;1. Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada;2. Department of Physiology, University of Toronto, Toronto, ON M5G 1X8, Canada;3. Department of Psychology, University of Toronto, Toronto, ON M5S 3G3, Canada;4. Institute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada |
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| Abstract: | Xenogeneic spinal cord chimeras were constructed by grafting fragments of quail neural primordium into chick embryos at 2 days of incubation. Hatched birds displayed normal motor behavior for about 5 to 7 weeks, whereupon they developed a neurological syndrome; in the grafted spinal cord the pathological signs of the disease were very similar to those of the active plaques of multiple sclerosis and of the lesions of experimental allergic encephalomyelitis and neuritis, including Ia expression by brain capillary endothelia, rupture of the blood-brain barrier, leukocytic infiltration in the nervous tissue, and demyelination. In the animals at the most advanced stage of the disease an autoimmune attack occurred on the host's nervous system with the same histopathological signs. |
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