Cardiac copper,magnesium, and zinc in recent and old myocardial infarction |
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Authors: | Nche Zama Robert L R Towns |
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Institution: | (1) Department of Chemistry, Cleveland State University, 44115 Cleveland, OH;(2) Present address: Dept. of Surgery, The Cleveland Clinic Foundation, 44106 Cleveland, OH |
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Abstract: | X-ray fluorescence spectrometry and atomic absorption spectrometry were used in a quantitative study of zinc, copper, and
magnesium in 71 postmortal human hearts. Samples were obtained from individuals who had demonstrated no previous clinical
or subsequent pathological findings of myocardial infarction and from victims of a recent or an old infarction. A significant
difference (p<0.001) in the elemental levels was observed between the noninfarct and the recent infarct groups. The noninfarct group had
higher cardiac levels of all three elements. However, the difference in elemental concentrations between the noninfarct and
the old-infarct groups was not significant. Cardiac levels of zinc (p<0.001) and copper (p<0.01) were significantly greater in the old-infarct group than in the recent-infarct group. Magnesium levels were higher
in the recent-and-old-infarct group than in the recent infarct group (p<0.01). It is possible that the elements are redistributed during myocardial infarction, and that uptake of these elements
(from the serum pool) by the heart may be important in maintaining myocardial integrity and function. |
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Keywords: | Myocardial analyses for zinc copper and magnesium myocardial infarction and cardiac zinc copper and magnesium copper zinc and magnesium in noninfarct recent-infarct old-infarct recent-and-old-infarct myocardium |
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