Two missense mutations in exon 9 of caprine PRLR gene were associated with litter size |
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| Authors: | J. X. Hou X. P. An P. Han J. Y. Peng B. Y. Cao |
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| Affiliation: | College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China |
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| Abstract: | ![]()
Guanzhong (n = 321) and Boer (n = 191) goat breeds were used to detect single nucleotide polymorphisms (SNPs) in the coding regions of the prolactin receptor (PRLR) gene by DNA sequencing and PCR‐RFLP. Two SNPs (c.1457G>A and c.1645G>A) were identified that caused amino acid variations p.Ser485Asn and p.Val548Met respectively. Statistical results indicated that the c.1457G>A and c.1645G>A SNPs were significantly associated with litter size in Boer and Guanzhong goat breeds. Further analysis revealed that combined genotype C4 (GGGG) and haplotype G‐G were better than the others for litter size in both goat breeds. These results might contribute to goat genetic resources and breeding. |
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| Keywords: | genotype PCR‐RFLP
breeding
SNP
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