Correlation between physico-chemical properties of quaternary ammonium salts of heptacaine and their inhibitory activity against photosynthesizing organisms |
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| Authors: | K. Král'ová D. Loos F. Šeršen J. Čižmárik |
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| Affiliation: | 1. Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina CH 2, 842 15, Bratislava, Slovakia
2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, Odbojárov 10, 832 32, Bratislava, Slovakia
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| Abstract: | Photosynthesis inhibition in algae (Chlorella) and plant (spinach) chloroplasts by quaternary ammonium salts of heptacaine {N-[2-(2-heptyloxyphenylcarbamoyloxy)-ethyl]-N-alkylpiperidinium bromides} depended on the alkyl chain length of the alkyl substituent and showed good correlations with theoretical hydrophobic fragment constants as well as with experimentally determined physico-chemical parameters, namely extraction constants and surface activities. Communicated by. Z. ŠESTáK |
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