The action of tellurite, a reagent for thiol groups, on mitochondria oxidative processes |
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| Authors: | D Siliprandi R H De Meio A Toninello F Zoccarato |
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| Affiliation: | Istituto di Chimica Biologica, Centro per lo Studio della Fisiologia dei Mitocondri del C.N.R., Padova, Italy |
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| Abstract: | Tellurite, a reagent for thiol groups, added to rat kidney, or liver mitochondria at the concentration of 1 mM, selectively inhibits the oxidation of NAD dependent substrates (pyruvate, α-ketoglutarate, glutamate, etc.) without affecting the oxidation of succinate, α-glycerophosphate and ascorbate. Moreover NADH oxidation by rat heart or by aged liver mitochondria is not affected by tellurite. |
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