基于CiteSpace分析铜绿假单胞菌耐药性研究热点与趋势

【背景】铜绿假单胞菌(Pseudomonas aeruginosa)是临床引发感染的主要病原菌之一，对多种抗菌药物均有耐药性，临床治疗难度大，对该病原菌耐药性的研究一直备受关注。【目的】基于CiteSpace可视化功能，探究铜绿假单胞菌耐药性研究现状、热点与发展趋势。【方法】利用文献计量分析法，以2014–2021年中国知网(CNKI)、万方数据库(Wanfang)、Web of Science (WoS)共8 996篇铜绿假单胞菌耐药性的中英文文献为分析样本，运用Citespace软件对文献发文量、作者合作网络、国家和机构合作网络、文献共被引及期刊分析、关键词聚类、突现等方面进行分析，以探究该研究主题的研究热点及趋势。【结果】英文文献发文量增长速度高于中文文献；我国文献发文量仅次于美国、印度，在该领域科研成果贡献度较高，国际学术影响力较大；中英文文献中均对院内感染疾病和耐碳青霉烯类铜绿假单胞菌持高关注度。然而，中文文献较关注铜绿假单胞菌耐药性的临床防治问题，英文文献则较关注铜绿假单胞菌耐药性的基础研究。【结论】国内外铜绿假单胞菌耐药性研究对院内感染疾病及新型耐药菌的产生与防治关注度最高，暗示以上研究主题是该领域的研究热点与趋势。

Research hotspots and trends of Pseudomonas aeruginosa drug resistance: a study based on CiteSpace

[Background] Pseudomonas aeruginosa, one of the main pathogens causing clinical infections, is resistant to a variety of antimicrobial agents, which is difficult to be treated in clinical practice. Increasing attention has been attached to the research on the drug resistance of P. aeruginosa. [Objective] With the visualization function of CiteSpace, we explored the status, hotspots and trend of the research on the drug resistance of P. aeruginosa. [Methods] We performed a bibliometric analysis involving 8 996 articles about the drug resistance of P. aeruginosa, which were published in Web of Science, CNKI, and Wanfang Data from 2014 to 2021. CiteSpace was used to analyze the number of articles published, author cooperation network, cooperation network of affiliated countries and institutions, and literature co-citation. Furthermore, we used CiteSpace to perform journal analysis, keyword clustering, and burst detection, aiming to reveal the hotspots and trends of this research field. [Results] The growth rate of the articles published in English was higher than that in Chinese. China ranked second only to the United States and India in the number of articles, showing great contribution to research achievements in this field and strong academic influence. The articles published in both Chinese and English concerned nosocomial infections and carbapenem-resistant P. aeruginosa. The difference was that papers published in Chinese focused more on the clinical prevention and treatment of drug resistance of P. aeruginosa, while those published in English mainly involved the basic research of the drug resistance. [Conclusion] The research on drug resistance of P. aeruginosa at home and abroad pays the highest attention to the production and control of new drug-resistant bacteria and nosocomial infection, suggesting that the above research topic is the research hotspot and trend in this field.