Synthesis of some new hybride molecules containing several azole moieties and investigation of their biological activities |
| |
Authors: | Sule Ceylan Hacer Bayrak Ahmet Demirbas Serdar Ulker Sengul Alpay-Karaoglu Neslihan Demirbas |
| |
Institution: | 1. Department of Forest Industrial Engineering, Artvin ?oruh University, Artvin, 08000, Turkey 2. Department of Chemistry, Karadeniz Technical University, Trabzon, 61080, Turkey 3. Department of Biology, Recep Tayyip Erdogan University, Rize, 5300, Turkey
|
| |
Abstract: | 1,2,4-Triazole-3-one prepared from tryptamine was converted to the corresponding carbothioamides by several steps. Their treatment with ethyl bromoacetate or 4-chlorophenacyl bromide produced the corresponding 5-oxo-1,3-thiazolidine or 3-(4-chlorophenyl)-1,3-thiazole derivatives. Acetohydrazide derivative that was obtained starting from tryptamine, was converted to the corresponding Schiff basis and sulfonamide by the treatment with suitable aldehydes and benzensulphonyl chloride, respectively. 2-(4-Amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazole-3-yl)methyl]-4-2-(1H-indole-3-yl)ethyl]-5-methyl-2,4-dihydro-3H-1,2,4-triazole-3-one was synthesized starting from hydrazide via the formation of the corresponding 1,3,4-oxadiazole compound, while the other bitriazole compounds were obtained by intramolecular cyclisation of carbothioamides in basic media. The treatment of 1,2,4-triazole or 1,3,4-oxadiazole compound with several amines generated the corresponding Mannich bases. Ethyl (2-amino-1,3-thiazole-4-yl)acetate was converted to the corresponding 1,3,4-oxadiazole derivative, arylidenehydrazides, 1,2,4-triazole-3-one and 5-oxo-1,3-oxazolidine derivatives by several steps. The structural assignments of new compounds were based on their elemental analysis and spectral (FT IR, 1H NMR, 13C NMR and LC-MS) data. The antimicrobial, antilipase and antiurease activity studies revealed that some of the synthesized compounds showed antimicrobial, antilipase and/or antiurease activity. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|