| DNA双链断裂损伤修复系统研究进展 |
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| 引用本文： | Huang M,Miao ZH,Ding J. DNA双链断裂损伤修复系统研究进展[J]. 生理科学进展, 2007, 38(4): 295-300 |
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| 作者姓名： | Huang M Miao ZH Ding J |
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| 作者单位： | 中国科学院上海药物研究所,国家新药研究重点实验室肿瘤药理组,上海,201203;中国科学院上海药物研究所,国家新药研究重点实验室肿瘤药理组,上海,201203;中国科学院上海药物研究所,国家新药研究重点实验室肿瘤药理组,上海,201203 |
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| 基金项目： | 中国科学院知识创新工程项目 |
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| 摘 要： | 多种内源或外源因素都能造成细胞基因组DNA损伤,细胞内建立了复杂的修复系统来应对不同形式的损伤。其中DNA双链断裂(DNA double-strand breaks,DSBs)作为最严重的损伤形式,主要激活同源重组修复(Homologous recombination repair)和非同源末端连接(Non-homologous end joining)通路。这两条通路都是由多个修复元件参与、经过多步反应的复杂过程。两者各具特点、协同作用,共同维护细胞基因组的稳定性。对其分子机制的阐明为肿瘤放化疗的辅助治疗提供了潜在的作用靶点。
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| 关 键 词： | DNA双链断裂 修复通路 同源重组修复 非同源末端连接 |
Repair pathways in response to DNA double-strand breaks |
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| Huang Min,Miao Ze-Hong,Ding Jian. Repair pathways in response to DNA double-strand breaks[J]. Progress in Physiological Sciences, 2007, 38(4): 295-300 |
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| Authors: | Huang Min Miao Ze-Hong Ding Jian |
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| Affiliation: | Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica , Chinese Academy of Sciences, Shanghai 201203, China |
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| Abstract: | DNA double-strand breaks (DSBs) are the principal cytotoxic lesions caused by many exogenous and endogenous factors. In response to DSBs, cells have evolved complex and highly conserved systems, which mainly consist of homologous recombination repair (HR) and non-homologous end joining (NHEJ) pathways, to effectively repair the lethal lesions. The two pathways play crucial roles in preserving the genomic integrity. Here, we provide an overview of detailed process, concerned molecules and regulatory factors in these pathways. Accumulated knowledge of DSBs repair may offer opportunities to develop more effective treatments for cancer. |
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| Keywords: | DNA double-strand breaks repair pathways homologous recombination repair non-homologous end joining |
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