| 微小RNA与细胞凋亡的研究进展 |
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| 引用本文： | Guo L,Ding ZH. 微小RNA与细胞凋亡的研究进展[J]. 生理科学进展, 2007, 38(4): 331-335 |
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| 作者姓名： | Guo L Ding ZH |
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| 作者单位： | 南方医科大学公共卫生与热带医学学院放射医学系,广州,510515;南方医科大学公共卫生与热带医学学院放射医学系,广州,510515 |
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| 摘 要： | 微小RNA(miRNAs)是最近发现的由18~24个核苷酸组成的RNA,通过对目标mRNA的抑制而发挥重要的调节作用。目前所有已研究的多细胞真核生物表明它们是通过miRNAs来调节细胞基本的生理功能,这些功能包括细胞的增殖、分化和死亡。本文讨论了miRNAs在调节细胞增殖和凋亡方面的功能:其中,抗凋亡的miRNAs有miR-17家族、miR-21、bantam和miR-14;促凋亡的miRNAs有let-7、miR-15a和miR-16。
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| 关 键 词： | 微小RNA 细胞增殖 凋亡 |
Advances in the studies of miRNAs and cell apoptosis |
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| Guo Ling,Ding Zhen-Hua. Advances in the studies of miRNAs and cell apoptosis[J]. Progress in Physiological Sciences, 2007, 38(4): 331-335 |
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| Authors: | Guo Ling Ding Zhen-Hua |
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| Affiliation: | Southern Medical University, Department of Radiation Medicine, Guangzhou 510515, China |
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| Abstract: | MicroRNAs (miRNAs) are a recently discovered class of 18 - 24 nucleotide RNA molecules that negatively regulate target mRNAs. All studied multicellular eukaryotes utilise miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. In this review, we will discuss the function of miRNAs that regulate cell proliferation and apoptosis. Antiapoptotic miRNAs include the miRNAs of the miR-17 cluster, miR-21, bantam and miR-14, Proapoptotic miRNAs include let-7, miR-15a and miR-16. |
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| Keywords: | MicroRNAs cell proliferation apoptosis |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
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