Neural and head induction by insulin-like growth factor signals. |
| |
Authors: | E M Pera O Wessely S Y Li E M De Robertis |
| |
Institution: | Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles 90095, USA. |
| |
Abstract: | Evidence is presented for a new pathway participating in anterior neural development. It was found that IGF binding protein 5 (IGFBP-5), as well as three IGFs expressed in early embryos, promoted anterior development by increasing the head region at the expense of the trunk in mRNA-injected Xenopus embryos. A secreted dominant-negative type I IGF receptor (DN-IGFR) had the opposite effect. IGF mRNAs led to the induction of ectopic eyes and ectopic head-like structures containing brain tissue. In ectodermal explants, IGF signals induced anterior neural markers in the absence of mesoderm formation and DN-IGFR inhibited neural induction by the BMP antagonist Chordin. Thus, active IGF signals appear to be both required and sufficient for anterior neural induction in Xenopus. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|