Therapeutic application of long-circulating liposomal glucocorticoids in auto-immune diseases and cancer |
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Authors: | Schiffelers Raymond M Banciu Manuela Metselaar Josbert M Storm Gert |
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Institution: | Dept. Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands. R.M.Schiffelers@pharm.uu.nl |
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Abstract: | Glucorticoids are potent drugs that have a multitude of pharmacological actions both at genomic and non-genomic levels. Many of the diseases in which glucorticoids are routinely administered are featured by angiogenesis and enhanced capillary permeability, permitting targeted delivery using long-circulating drug delivery systems. By encapsulation of glucorticoids in long-circulating liposomes, drug levels at the site of the pathology are markedly higher, increasing and prolonging therapeutic efficacy in models of rheumatoid arthritis, multiple sclerosis, and cancer. |
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