Control of redox reactivity of flavin and pterin coenzymes by metal ion coordination and hydrogen bonding |
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Authors: | Shunichi Fukuzumi Takahiko Kojima |
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Institution: | (1) Department of Material and Life Science, Graduate School of Engineering, Osaka University, SORST, Japan Science and Technology Agency, 2-1 Yamada-oka, Suita, Osaka 565-0871, Japan |
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Abstract: | The electron-transfer activities of flavin and pterin coenzymes can be fine-tuned by coordination of metal ions, protonation
and hydrogen bonding. Formation of hydrogen bonds with a hydrogen-bond receptor in metal–flavin complexes is made possible
depending on the type of coordination bond that can leave the hydrogen-bonding sites. The electron-transfer catalytic functions
of flavin and pterin coenzymes are described by showing a number of examples of both thermal and photochemical redox reactions,
which proceed by controlling the electron-transfer reactivity of coenzymes with metal ion binding, protonation and hydrogen
bonding. |
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Keywords: | Cofactor Electron transfer Photoreduction Flavin Pterin |
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