Immunoglobulin isoantigens (allotypes) in the mouse |
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| Authors: | Samuel J. Black James W. Goding George A. Gutman Leonard A. Herzenberg Michael R. Loken Barbara A. Osborne Wessel van der Loo Noel L. Warner |
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| Affiliation: | (1) Department of Genetics, Stanford University School of Medicine, 94305 Stanford, California;(2) The Walter and Eliza Hall Institute of Medical Research, c/o Royal Melbourne Hospital Post Office, 3050 Victoria, Australia |
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| Abstract: | Murine antisera raised against allogeneic lymphoid cells often contain antibodies to IgM allotypes. Rarely, allotypic antibodies to IgM have been found after immunization withB. pertussis anti-B. pertussis conjugates. Using both types of antibodies, we have defined a new constant-region locus for both secreted and membrane-bound  chains. This locus,Ig-6, is closely linked to the previously described H-chain constant-region loci (Ig-1 throughIg-5) and is subject to allelic exclusion. We have identified three alleles and four antigenic specificities ofIg-6.Authors listed alphabetically |
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