Primary structure, recombinant expression, and molecular characterization of Phl p 4, a major allergen of timothy grass (Phleum pratense) |
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Authors: | Nandy Andreas Petersen Arnd Wald Martin Suck Roland Kahlert Helga Weber Bernhard Becker Wolf-Meinhard Cromwell Oliver Fiebig Helmut |
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Institution: | Allergopharma Joachim Ganzer KG, Research and Development, Reinbek, Germany. andreas.nandy@allergopharma.de |
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Abstract: | Grass pollen allergy is one of the most important allergic diseases world-wide. Several meadow grasses, like timothy grass and rye grass, contribute to allergic sensitizations, but also allergens from extensively cultivated cereals, especially rye, make a profound contribution. The group 4 allergens are well known as important major allergens of grasses. We have cloned for the first time group 4 sequences from Phleum pratense, Lolium perenne, Secale cereale, Triticum aestivum, and Hordeum vulgare, and investigated the IgE-reactivity of recombinant Phl p 4 as a candidate for allergy diagnostic and therapeutic applications. |
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Keywords: | Type I allergy Grass group 4 allergen Phl p 4 Phleum pratense Flavoprotein Recombinant allergen |
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