A study of the inability of subcellular fractions to elicit primary anti-H-2 cytotoxic T lymphocytes |
| |
Authors: | Arthur H Hale Maria P McGee |
| |
Institution: | Department of Microbiology and Immunology, The Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103 U.S.A. |
| |
Abstract: | An analysis was undertaken to understand the inability of H-2 containing plasma membranes and partially purified H-2 antigens incorporated into lipid vesicles to elicit primary anti-H-2 CTLs. It was found that in the presence of supernatants from concanavalin A stimulated spleen cells H-2 containing-subcellular fractions could elicit anti-H-2 CTLs. The result suggests that cytotoxic T lymphocyte precursor cells are available for interaction with alloantigens within the subcellular fractions and that the defect is the inability of these H-2 antigen-containing subcellular fractions to stimulate T helper activity. |
| |
Keywords: | To whom requests for reprints should be addressed |
本文献已被 ScienceDirect 等数据库收录! |